Standard
Cutaneous malignant melanoma
CCND1 · rs498136
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cutaneous malignant melanoma compared to the general population.
A/C
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cutaneous malignant melanoma.
C/C
Published research associates this genotype with typical/baseline likelihood of Cutaneous malignant melanoma — no copies of the reported risk allele.
Source
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Law MH,
Bishop DT,
Lee JE,
Brossard M,
Martin NG,
Moses EK,
Song F,
Barrett JH,
Kumar R,
Easton DF,
Pharoah PDP,
Swerdlow AJ
and 63 more — show all
Kypreou KP,
Taylor JC,
Harland M,
Randerson-Moor J,
Akslen LA,
Andresen PA,
Avril MF,
Azizi E,
Scarrà GB,
Brown KM,
Dębniak T,
Duffy DL,
Elder DE,
Fang S,
Friedman E,
Galan P,
Ghiorzo P,
Gillanders EM,
Goldstein AM,
Gruis NA,
Hansson J,
Helsing P,
Hočevar M,
Höiom V,
Ingvar C,
Kanetsky PA,
Chen WV,
Landi MT,
Lang J,
Lathrop GM,
Lubiński J,
Mackie RM,
Mann GJ,
Molven A,
Montgomery GW,
Novaković S,
Olsson H,
Puig S,
Puig-Butille JA,
Qureshi AA,
Radford-Smith GL,
van der Stoep N,
van Doorn R,
Whiteman DC,
Craig JE,
Schadendorf D,
Simms LA,
Burdon KP,
Nyholt DR,
Pooley KA,
Orr N,
Stratigos AJ,
Cust AE,
Ward SV,
Hayward NK,
Han J,
Schulze HJ,
Dunning AM,
Bishop JAN,
Demenais F,
Amos CI,
MacGregor S,
Iles MM
Nature genetics · 2015 · PMID 26237428 · open access
Questions about rs498136
What is rs498136?
rs498136 is a single position in the genome, in or near the CCND1 gene. Published research associates it with cutaneous malignant melanoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs498136 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs498136 come from?
GWAS Catalog, Nat Genet 2015, PMID:26237428. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants