Sensitive

Broad depression or schizophrenia

TSNARE1 · rs4976976

Where this position leads

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Broad depression or schizophrenia compared to the general population. (GWAS Catalog, Mol Psychiatry 2019, PMID:30626913)

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Broad depression or schizophrenia. (GWAS Catalog, Mol Psychiatry 2019, PMID:30626913)

G/G Published research associates this genotype with typical/baseline likelihood of Broad depression or schizophrenia — no copies of the reported risk allele. (GWAS Catalog, Mol Psychiatry 2019, PMID:30626913)

Source

Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression

Amare AT, Vaez A, Hsu YH, Direk N, Kamali Z, Howard DM, McIntosh AM, McIntosh AM, Tiemeier H, Bültmann U, Snieder H, Hartman CA

Molecular psychiatry · 2020 · PMID 30626913 · open access

Questions about rs4976976

What is rs4976976?

rs4976976 is a single position in the genome, in or near the TSNARE1 gene. Published research associates it with broad depression or schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4976976 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs4976976 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4976976 come from?

GWAS Catalog, Mol Psychiatry 2019, PMID:30626913. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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