Sensitive

Colorectal cancer x fine particulate matter exposure levels interaction

NRXN1 · rs4971775

Where this position leads

Condition: Colorectal Cancer

rs4971775 Condition: Colorectal Cancer Colorectal Cancer Condition rs4971775 rs4971775 NRXN1

What the study found

Who was studied 590 European ancestry cases, 55 Black cases, 9 Hispanic cases, 28 Asian ancestry cases, 5 cases, 12,715 European ancestry controls, 1,153 Black controls, 37 Hispanic controls, 94 Asian ancestry controls, 15 controls.

The effect Each copy of the G allele carried 1.21 times the odds of Colorectal cancer x fine particulate matter exposure levels interaction (95% confidence interval 1.14-1.29); p = 4 × 10−9.

How common The G allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 2, band 2p16.3 — in an intron of NRXN1-DT.

What each result means

G/G Two copies of the version the research linked to Colorectal cancer x fine particulate matter exposure levels interaction. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Colorectal cancer x fine particulate matter exposure levels interaction. That is a smaller link than two copies.
T/T No copy of the version the research linked to Colorectal cancer x fine particulate matter exposure levels interaction. This is the starting point the study compared everyone against.
Source

Questions about rs4971775

What is rs4971775?

rs4971775 is a single position in the genome, in or near the NRXN1 gene. Published research associates it with colorectal cancer x fine particulate matter exposure levels interaction. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4971775 linked to?

On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs4971775 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4971775 come from?

GWAS Catalog, Environ Int 2020, PMID:33338681. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Colorectal cancer x fine particulate matter exposure levels interaction (rs4971775). MyGeneLog™. https://www.mygenelog.com/variants/rs4971775

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