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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 651,923 European ancestry males, 679,087 European ancestry females.
The effect
Each copy of the G allele carried 1.08 times the odds of Insomnia (95% confidence interval 1.05-1.10); p = 3 × 10−8.
How common The G allele had a frequency of about 84% in the people studied.
Where it sits Chromosome 5, band 5q21.3 — in an intron of FBXL17.
What each result means
A/ANo copy of the version the research linked to Insomnia. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Insomnia. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Insomnia. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs4957727 is a single position in the genome, in or near the FBXL17 gene. Published research associates it with insomnia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4957727 linked to?
On MyGeneLog this position is linked to Insomnia. The research behind each link, and its sources, are set out on that condition page.
Does having rs4957727 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4957727 come from?
GWAS Catalog, Nature genetics 2019, PMID:30804565. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license