Sensitive

Coronary artery disease

near HNRNPKP2 · rs4954580

Where this position leads

What the study found

Who was studied 210,842 European ancestry, East Asian ancestry, unknown cases, 1,167,328 European ancestry, East Asian ancestry, unknown controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 3 × 10⁻⁹.

How common The T allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 2, band 2q22.1 — between genes, 28.2 kb from HNRNPKP2.

What each result means

C/C No copy of the version the research linked to Coronary artery disease. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Coronary artery disease. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, Weeks EM, Wang M, Hindy G, Zhou W, Grace C, Roselli C

and 83 more — show all

Marston NA, Kamanu FK, Surakka I, Venegas LM, Sherliker P, Koyama S, Ishigaki K, Åsvold BO, Brown MR, Brumpton B, de Vries PS, Giannakopoulou O, Giardoglou P, Gudbjartsson DF, Güldener U, Haider SMI, Helgadottir A, Ibrahim M, Kastrati A, Kessler T, Kyriakou T, Konopka T, Li L, Ma L, Meitinger T, Mucha S, Munz M, Murgia F, Nielsen JB, Nöthen MM, Pang S, Reinberger T, Schnitzler G, Smedley D, Thorleifsson G, von Scheidt M, Ulirsch JC, Arnar DO, Burtt NP, Costanzo MC, Flannick J, Ito K, Jang DK, Kamatani Y, Khera AV, Komuro I, Kullo IJ, Lotta LA, Nelson CP, Roberts R, Thorgeirsson G, Thorsteinsdottir U, Webb TR, Baras A, Björkegren JLM, Boerwinkle E, Dedoussis G, Holm H, Hveem K, Melander O, Morrison AC, Orho-Melander M, Rallidis LS, Ruusalepp A, Sabatine MS, Stefansson K, Zalloua P, Ellinor PT, Farrall M, Danesh J, Ruff CT, Finucane HK, Hopewell JC, Clarke R, Gupta RM, Erdmann J, Samani NJ, Schunkert H, Watkins H, Willer CJ, Deloukas P, Kathiresan S, Butterworth AS

Biobank Japan · EPIC-CVD · CARDIoGRAMplusC4D Consortium

Nature genetics · 2022 · PMID 36474045 · open access

Questions about rs4954580

What is rs4954580?

rs4954580 is a single position in the genome, in or near the near HNRNPKP2 gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4954580 linked to?

On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs4954580 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4954580 come from?

GWAS Catalog, Nature genetics 2022, PMID:36474045. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Coronary artery disease (rs4954580). MyGeneLog™. https://www.mygenelog.com/variants/rs4954580

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