Standard
Red blood cell traits
PRKCE · rs4953318
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Red blood cell traits compared to the general population. (GWAS Catalog, Nature 2012, PMID:23222517)
A/C
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Red blood cell traits. (GWAS Catalog, Nature 2012, PMID:23222517)
C/C
Published research associates this genotype with typical/baseline likelihood of Red blood cell traits — no copies of the reported risk allele. (GWAS Catalog, Nature 2012, PMID:23222517)
Source
Seventy-five genetic loci influencing the human red blood cell
van der Harst P,
Zhang W,
Mateo Leach I,
Rendon A,
Verweij N,
Sehmi J,
Paul DS,
Elling U,
Allayee H,
Li X,
Radhakrishnan A,
Tan ST
and 183 more — show all
Voss K,
Weichenberger CX,
Albers CA,
Al-Hussani A,
Asselbergs FW,
Ciullo M,
Danjou F,
Dina C,
Esko T,
Evans DM,
Franke L,
Gögele M,
Hartiala J,
Hersch M,
Holm H,
Hottenga JJ,
Kanoni S,
Kleber ME,
Lagou V,
Langenberg C,
Lopez LM,
Lyytikäinen LP,
Melander O,
Murgia F,
Nolte IM,
O'Reilly PF,
Padmanabhan S,
Parsa A,
Pirastu N,
Porcu E,
Portas L,
Prokopenko I,
Ried JS,
Shin SY,
Tang CS,
Teumer A,
Traglia M,
Ulivi S,
Westra HJ,
Yang J,
Zhao JH,
Anni F,
Abdellaoui A,
Attwood A,
Balkau B,
Bandinelli S,
Bastardot F,
Benyamin B,
Boehm BO,
Cookson WO,
Das D,
de Bakker PI,
de Boer RA,
de Geus EJ,
de Moor MH,
Dimitriou M,
Domingues FS,
Döring A,
Engström G,
Eyjolfsson GI,
Ferrucci L,
Fischer K,
Galanello R,
Garner SF,
Genser B,
Gibson QD,
Girotto G,
Gudbjartsson DF,
Harris SE,
Hartikainen AL,
Hastie CE,
Hedblad B,
Illig T,
Jolley J,
Kähönen M,
Kema IP,
Kemp JP,
Liang L,
Lloyd-Jones H,
Loos RJ,
Meacham S,
Medland SE,
Meisinger C,
Memari Y,
Mihailov E,
Miller K,
Moffatt MF,
Nauck M,
Novatchkova M,
Nutile T,
Olafsson I,
Onundarson PT,
Parracciani D,
Penninx BW,
Perseu L,
Piga A,
Pistis G,
Pouta A,
Puc U,
Raitakari O,
Ring SM,
Robino A,
Ruggiero D,
Ruokonen A,
Saint-Pierre A,
Sala C,
Salumets A,
Sambrook J,
Schepers H,
Schmidt CO,
Silljé HH,
Sladek R,
Smit JH,
Starr JM,
Stephens J,
Sulem P,
Tanaka T,
Thorsteinsdottir U,
Tragante V,
van Gilst WH,
van Pelt LJ,
van Veldhuisen DJ,
Völker U,
Whitfield JB,
Willemsen G,
Winkelmann BR,
Wirnsberger G,
Algra A,
Cucca F,
d'Adamo AP,
Danesh J,
Deary IJ,
Dominiczak AF,
Elliott P,
Fortina P,
Froguel P,
Gasparini P,
Greinacher A,
Hazen SL,
Jarvelin MR,
Khaw KT,
Lehtimäki T,
Maerz W,
Martin NG,
Metspalu A,
Mitchell BD,
Montgomery GW,
Moore C,
Navis G,
Pirastu M,
Pramstaller PP,
Ramirez-Solis R,
Schadt E,
Scott J,
Shuldiner AR,
Smith GD,
Smith JG,
Snieder H,
Sorice R,
Spector TD,
Stefansson K,
Stumvoll M,
Tang WH,
Toniolo D,
Tönjes A,
Visscher PM,
Vollenweider P,
Wareham NJ,
Wolffenbuttel BH,
Boomsma DI,
Beckmann JS,
Dedoussis GV,
Deloukas P,
Ferreira MA,
Sanna S,
Uda M,
Hicks AA,
Penninger JM,
Gieger C,
Kooner JS,
Ouwehand WH,
Soranzo N,
Chambers JC
Nature · 2012 · PMID 23222517
Questions about rs4953318
What is rs4953318?
rs4953318 is a single position in the genome, in or near the PRKCE gene. Published research associates it with red blood cell traits. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4953318 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4953318 come from?
GWAS Catalog, Nature 2012, PMID:23222517. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants