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Who was studied 1,283 Latino cases, 2,027 Latino controls; replicated in 448 African American cases, 595 African American controls.
The effect
Each copy of the A allele carried 1.39 times the odds of Asthma with severe exacerbations (95% confidence interval 1.23-1.56); p = 4 × 10−8.
Where it sits Chromosome 2, band 2p21 — between genes, 30 kb from LDHAP3.
What each result means
A/ATwo copies of the version the research linked to Asthma with severe exacerbations. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Asthma with severe exacerbations. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Asthma with severe exacerbations. This is the starting point the study compared everyone against.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021 · PMID 32841424
Questions about rs4952375
What is rs4952375?
rs4952375 is a single position in the genome, in or near the snoZ247 gene. Published research associates it with asthma with severe exacerbations. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4952375 linked to?
On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.
Does having rs4952375 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4952375 come from?
GWAS Catalog, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2021, PMID:32841424. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Asthma with severe exacerbations (rs4952375). MyGeneLog™. https://www.mygenelog.com/variants/rs4952375