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PDE4B · rs495054
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
Its strongest genetic-study result is p = 10−10, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 593,724 European ancestry cases, 1,771,286 European ancestry controls.
The effect Each copy of the A allele shifted the measure 0.006 higher (95% confidence interval 0.004-0.008); p = 8 × 10−11.
Where it sits Chromosome 1, band 1p31.3 — in an intron of PDE4B.
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Insomnia (rs495054). MyGeneLog™. https://www.mygenelog.com/variants/rs495054