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Vitamin D insufficiency

NADSYN1 · rs4944958

Where this position leads

Condition: Vitamin D Deficiency and the GC Gene

rs4944958 Condition: Vitamin D Deficiency and the GC Gene Vitamin D Deficiency and the GC Gene Condition rs4944958 rs4944958 NADSYN1

What the study found

Who was studied 35,079 European ancestry cases, 140,898 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.259 higher (95% confidence interval 0.24-0.28); p = 9 × 10−143.

How common The A allele had a frequency of about 20% in the people studied.

Where it sits Chromosome 11, band 11q13.4 — in an intron of NADSYN1.

What each result means

A/A Two copies of the version the research linked to Vitamin D insufficiency. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Vitamin D insufficiency. That is a smaller link than two copies.
G/G No copy of the version the research linked to Vitamin D insufficiency. This is the starting point the study compared everyone against.
Source

Questions about rs4944958

What is rs4944958?

rs4944958 is a single position in the genome, in or near the NADSYN1 gene. Published research associates it with vitamin d insufficiency. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4944958 linked to?

On MyGeneLog this position is linked to Vitamin D Deficiency and the GC Gene. The research behind each link, and its sources, are set out on that condition page.

Does having rs4944958 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4944958 come from?

GWAS Catalog, BMJ nutrition, prevention & health 2021, PMID:34308111. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Vitamin D insufficiency (rs4944958). MyGeneLog™. https://www.mygenelog.com/variants/rs4944958

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