Standard
Primary biliary cholangitis
POU2AF1 · rs4938534
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Primary biliary cholangitis compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Primary biliary cholangitis.
G/G
Published research associates this genotype with typical/baseline likelihood of Primary biliary cholangitis — no copies of the reported risk allele.
Source
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population
Nakamura M,
Nishida N,
Kawashima M,
Aiba Y,
Tanaka A,
Yasunami M,
Nakamura H,
Komori A,
Nakamuta M,
Zeniya M,
Hashimoto E,
Ohira H
and 68 more — show all
Yamamoto K,
Onji M,
Kaneko S,
Honda M,
Yamagiwa S,
Nakao K,
Ichida T,
Takikawa H,
Seike M,
Umemura T,
Ueno Y,
Sakisaka S,
Kikuchi K,
Ebinuma H,
Yamashiki N,
Tamura S,
Sugawara Y,
Mori A,
Yagi S,
Shirabe K,
Taketomi A,
Arai K,
Monoe K,
Ichikawa T,
Taniai M,
Miyake Y,
Kumagi T,
Abe M,
Yoshizawa K,
Joshita S,
Shimoda S,
Honda K,
Takahashi H,
Hirano K,
Takeyama Y,
Harada K,
Migita K,
Ito M,
Yatsuhashi H,
Fukushima N,
Ota H,
Komatsu T,
Saoshiro T,
Ishida J,
Kouno H,
Kouno H,
Yagura M,
Kobayashi M,
Muro T,
Masaki N,
Hirata K,
Watanabe Y,
Nakamura Y,
Shimada M,
Hirashima N,
Komeda T,
Sugi K,
Koga M,
Ario K,
Takesaki E,
Maehara Y,
Uemoto S,
Kokudo N,
Tsubouchi H,
Mizokami M,
Nakanuma Y,
Tokunaga K,
Ishibashi H
American journal of human genetics · 2012 · PMID 23000144
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs4938534
What is rs4938534?
rs4938534 is a single position in the genome, in or near the POU2AF1 gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What do people read about alongside rs4938534?
Subjects that appear in the title or abstract of the same papers as this rsID include liver (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs4938534 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4938534 come from?
GWAS Catalog, Am J Hum Genet 2012, PMID:23000144. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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