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Corneal structure

ARHGAP20 · rs4938174

Where this position leads

Condition: Central Corneal Thickness

rs4938174 Condition: Central Corneal Thickness Central Corneal Thickness Condition rs4938174 rs4938174 ARHGAP20

What the study found

Who was studied 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.06 higher (95% confidence interval 0.04-0.08); p = 4 × 10−9.

How common The A allele had a frequency of about 31% in the people studied.

Where it sits Chromosome 11, band 11q23.1 — between genes, 2.3 kb from RNA5SP350.

What each result means

A/A Two copies of the version the research linked to Corneal structure. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Corneal structure. That is a smaller link than two copies.
G/G No copy of the version the research linked to Corneal structure. This is the starting point the study compared everyone against.
Source

Questions about rs4938174

What is rs4938174?

rs4938174 is a single position in the genome, in or near the ARHGAP20 gene. Published research associates it with corneal structure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4938174 linked to?

On MyGeneLog this position is linked to Central Corneal Thickness. The research behind each link, and its sources, are set out on that condition page.

Does having rs4938174 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4938174 come from?

GWAS Catalog, Nat Genet 2013, PMID:23291589. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Corneal structure (rs4938174). MyGeneLog™. https://www.mygenelog.com/variants/rs4938174

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