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Body mass index

BUD13 · rs4936356

Where this position leads

Conditions: Obesity and Body Weight, Childhood Body Mass Index

rs4936356 Condition: Obesity and Body Weight Obesity and Body Weight Condition Condition: Childhood Body Mass Index Childhood Body Mass Index Condition rs4936356 rs4936356 BUD13

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 4,626 Greenlandic individuals; replicated in 1,529 Greenlandic individuals, 1,058 Yup’ik Alaska Native ancestry individuals.

The effect The reported allele is G; the catalogue records no effect size ; p = 5 × 10−8.

How common The G allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 11, band 11q23.3 — between genes, 60.1 kb from LINC02151.

What each result means

A/A No copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Body mass index. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs4936356

What is rs4936356?

rs4936356 is a single position in the genome, in or near the BUD13 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4936356 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight, Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.

Does having rs4936356 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4936356 come from?

GWAS Catalog, PLoS genetics 2020, PMID:31978080. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Body mass index (rs4936356). MyGeneLog™. https://www.mygenelog.com/variants/rs4936356

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