Standard
Age-related macular degeneration
ALDH1A2 · rs493258
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Age-related macular degeneration compared to the general population.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Age-related macular degeneration.
T/T
Published research associates this genotype with typical/baseline likelihood of Age-related macular degeneration — no copies of the reported risk allele.
Source
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
Neale BM,
Fagerness J,
Reynolds R,
Sobrin L,
Parker M,
Raychaudhuri S,
Tan PL,
Oh EC,
Merriam JE,
Souied E,
Bernstein PS,
Li B
and 14 more — show all
Frederick JM,
Zhang K,
Brantley MA Jr,
Lee AY,
Zack DJ,
Campochiaro B,
Campochiaro P,
Ripke S,
Smith RT,
Barile GR,
Katsanis N,
Allikmets R,
Daly MJ,
Seddon JM
Proceedings of the National Academy of Sciences of the United States of America · 2010 · PMID 20385826
Questions about rs493258
What is rs493258?
rs493258 is a single position in the genome, in or near the ALDH1A2 gene. Published research associates it with age-related macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs493258 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs493258 come from?
GWAS Catalog, Proc Natl Acad Sci U S A 2010, PMID:20385826. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants