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Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 2,964 Japanese ancestry case, 61,887 Japanese ancestry controls, 7,481 European ancestry cases, 9,250 European ancestry controls.
The effect
Each copy of the G allele carried 1.13 times the odds of Bipolar disorder (95% confidence interval 1.08856333588057-1.17748461027614); p = 6 × 10−10.
Where it sits Chromosome 19, band 19p13.13 — in an intron of NFIX.
How common each version is
AG
KoreanKRGDB
A 64.8% · G 35.1%
KoreanKorea4K
A 64.6% · G 35.4%
Japanese ToMMo
A 64.5% · G 35.5%
Vietnamese
A 60.6% · G 39.4%
World gnomAD
A 48.7% · G 51.3%
World 1000 Genomes
A 58.6% · G 41.4%
World TOPMed
A 51.6% · G 48.4%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
A/ANo copy of the version the research linked to Bipolar disorder. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Bipolar disorder. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Bipolar disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
Molecular psychiatry · 2018 · PMID 28115744 · open access
Questions about rs4926298
What is rs4926298?
rs4926298 is a single position in the genome, in or near the NFIX gene. Published research associates it with bipolar disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4926298 linked to?
On MyGeneLog this position is linked to Bipolar Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs4926298 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4926298 come from?
GWAS Catalog, Mol Psychiatry 2017, PMID:28115744. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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