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CRISP2 protein levels

MGA · rs4924567

Where this position leads

Condition: Celiac Disease

rs4924567 Condition: Celiac Disease Celiac Disease Condition rs4924567 rs4924567 MGA

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0339 lower (95% confidence interval 0.025-0.043); p = 4 × 10−17.

How common The T allele had a frequency of about 80% in the people studied.

Where it sits Chromosome 15, band 15q15.1 — in an intron of MGA.

What each result means

A/A No copy of the version the research linked to CRISP2 protein levels. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to CRISP2 protein levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to CRISP2 protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs4924567

What is rs4924567?

rs4924567 is a single position in the genome, in or near the MGA gene. Published research associates it with crisp2 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4924567 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs4924567 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4924567 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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CRISP2 protein levels (rs4924567). MyGeneLog™. https://www.mygenelog.com/variants/rs4924567

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