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Prostate cancer

KRT8 · rs4919743

Where this position leads

Condition: Prostate Cancer

rs4919743 Condition: Prostate Cancer Prostate Cancer Condition rs4919743 rs4919743 KRT8

What the study found

Who was studied 5,764 African American or Afro-Caribbean cases, 42,247 African American or Afro-Caribbean controls, 28,645 European ancestry cases, 264,556 European ancestry controls, 1,678 Hispanic or Latin American cases, 24,750 Hispanic or Latin American controls.

The effect Each copy of the G allele shifted the measure 0.167 lower (95% confidence interval 0.15-0.19); p = 9 × 10−36.

How common The G allele had a frequency of about 88% in the people studied.

Where it sits Chromosome 12, band 12q13.13 — in an intron of KRT8.

What each result means

A/A No copy of the version the research linked to Prostate cancer. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Prostate cancer. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Prostate cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs4919743

What is rs4919743?

rs4919743 is a single position in the genome, in or near the KRT8 gene. Published research associates it with prostate cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4919743 linked to?

On MyGeneLog this position is linked to Prostate Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs4919743 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4919743 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Prostate cancer (rs4919743). MyGeneLog™. https://www.mygenelog.com/variants/rs4919743

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