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Who was studied 180 Brazilian ancestry low dose individuals, 187 Brazilian ancestry high dose individuals; replicated in 798 European ancestry individuals, 1611 Japanese ancestry individuals, 191 African American individuals.
The effect
The reported allele is C; the catalogue records no effect size
; p = 2 × 10−13.
Where it sits Chromosome 10, band 10q23.33 — between genes, 0.6 kb from CYP2C9.
What each result means
A/ANo copy of the version the research linked to Warfarin maintenance dose. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Warfarin maintenance dose. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Warfarin maintenance dose. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs4918798 is a single position in the genome, in or near the CYP2C9 gene. Published research associates it with warfarin maintenance dose. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs4918798 affect how medicines work?
CYP2C9 carries pharmacogenomic findings for Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs4918798 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4918798 come from?
GWAS Catalog, Pharmacogenomics 2015, PMID:26265036. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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