PLCE1 · rs4918188
Where this position leads
Condition: Obesity and Body Weight
What the study found
Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.007 lower (95% confidence interval 0.0045-0.0095); p = 3 × 10−8.
Where it sits Chromosome 10, band 10q23.33 — in an intron of PLCE1.
What ClinVar records
Classification
Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-11-12.
ClinVar record 1264955 NM_016341.4(PLCE1):c.4665+289A>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs4918188 is a single position in the genome, in or near the PLCE1 gene. Published research associates it with weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Weight (rs4918188). MyGeneLog™. https://www.mygenelog.com/variants/rs4918188