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Exotropia

near UTS2 · rs4908704

Where this position leads

What the study found

Who was studied 3,998 European ancestry cases, 583,468 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.089 lower (95% confidence interval 0.064-0.114); p = 1 × 10⁻¹¹.

How common The A allele had a frequency of about 76% in the people studied.

Where it sits Chromosome 1, band 1p36.23 — between genes, 5.3 kb from UTS2.

What each result means

A/A Two copies of the version the research linked to Exotropia. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Exotropia. That is a smaller link than two copies.

G/G No copy of the version the research linked to Exotropia. This is the starting point the study compared everyone against.

Source

Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking

He W, van der Most PJ, Ong JS, Hwang LD, Wu Y, Magnø MS, Vehof J, Krebs K, Mauring L, Õunap K, Abner E, Martin NG

and 12 more — show all

Plotnikov D, Jiang C, Melles RB, Gharahkhani P, Snieder H, Palumaa T, Kaljurand K, Guggenheim JA, Mackey DA, Engle EC, Choquet H, MacGregor S

Lifelines Cohort Study

Nature communications · 2025 · PMID 40849414 · open access

Questions about rs4908704

What is rs4908704?

rs4908704 is a single position in the genome, in or near the near UTS2 gene. Published research associates it with exotropia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4908704 linked to?

On MyGeneLog this position is linked to Exotropia. The research behind each link, and its sources, are set out on that condition page.

Does having rs4908704 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4908704 come from?

GWAS Catalog, Nature communications 2025, PMID:40849414. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Exotropia (rs4908704). MyGeneLog™. https://www.mygenelog.com/variants/rs4908704

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