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Who was studied at least 757,601 European ancestry individuals (MTAG boosted by 455,258 Alzheimer's disease samples).
The effect
Each copy of the G allele shifted the measure 0.0125 lower (95% confidence interval 0.0089-0.0162); p = 1 × 10−11.
Where it sits Chromosome 1, band 1p35.3 — in an intron of PHACTR4.
What each result means
G/GTwo copies of the version the research linked to Systolic blood pressure (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Systolic blood pressure (MTAG). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Systolic blood pressure (MTAG). This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39537608 · open access
Questions about rs4908348
What is rs4908348?
rs4908348 is a single position in the genome, in or near the PHACTR4 gene. Published research associates it with systolic blood pressure (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4908348 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs4908348 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4908348 come from?
GWAS Catalog, Nature communications 2024, PMID:39537608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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