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Asthma

TRAF3 · rs4906259

Where this position leads

Condition: Asthma

rs4906259 Condition: Asthma Asthma Condition rs4906259 rs4906259 TRAF3

What the study found

Who was studied 64,538 European ancestry cases, 239,321 European ancestry controls.

The effect Each copy of the C allele carried 1.05 times the odds of Asthma (95% confidence interval 1.03374584627989-1.06660629287547); p = 1 × 10−9.

How common The C allele had a frequency of about 17% in the people studied.

Where it sits Chromosome 14, band 14q32.32 — between genes, 15.2 kb from TRAF3.

What each result means

C/C Two copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Asthma. That is a smaller link than two copies.
T/T No copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
Source

Questions about rs4906259

What is rs4906259?

rs4906259 is a single position in the genome, in or near the TRAF3 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4906259 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs4906259 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4906259 come from?

GWAS Catalog, Nature communications 2020, PMID:32296059. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs4906259). MyGeneLog™. https://www.mygenelog.com/variants/rs4906259

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