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Cholesteryl Esters to Total Lipids in IDL percentage

FOXN3 · rs4904549

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs4904549 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs4904549 rs4904549 FOXN3

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the T allele shifted the measure 0.02 % lower (95% confidence interval 0.02-0.02); p = 6 × 10−11.

Where it sits Chromosome 14, band 14q32.11 — in an intron of FOXN3.

What each result means

C/C No copy of the version the research linked to Cholesteryl Esters to Total Lipids in IDL percentage. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Cholesteryl Esters to Total Lipids in IDL percentage. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cholesteryl Esters to Total Lipids in IDL percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs4904549

What is rs4904549?

rs4904549 is a single position in the genome, in or near the FOXN3 gene. Published research associates it with cholesteryl esters to total lipids in idl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4904549 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs4904549 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4904549 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cholesteryl Esters to Total Lipids in IDL percentage (rs4904549). MyGeneLog™. https://www.mygenelog.com/variants/rs4904549

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