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Sensitive

Graves' disease

TSHR · rs4903961

Where this position leads

Condition: Graves' Disease

rs4903961 Condition: Graves' Disease Graves' Disease Condition rs4903961 rs4903961 TSHR

What the study found

Who was studied 2,176 Japanese ancestry cases, 210,277 Japanese ancestry controls.

The effect Each copy of the G allele carried 1.26 times the odds of Graves' disease (95% confidence interval 1.187528644-1.345587164); p = 2 × 10−13.

How common The G allele had a frequency of about 61% in the people studied.

Where it sits Chromosome 14, band 14q31.1 — in an intron of TSHR.

What each result means

C/C No copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
C/G One copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T
and 77 more — show all
Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y
Nature genetics · 2020 · PMID 32514122

Questions about rs4903961

What is rs4903961?

rs4903961 is a single position in the genome, in or near the TSHR gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4903961 linked to?

On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs4903961 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4903961 come from?

GWAS Catalog, Nature genetics 2020, PMID:32514122. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Graves' disease (rs4903961). MyGeneLog™. https://www.mygenelog.com/variants/rs4903961

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