Standard
Heart rate variability traits (SDNN)
RGS6 · rs4899412
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Heart rate variability traits (SDNN) — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Heart rate variability traits (SDNN).
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Heart rate variability traits (SDNN) compared to the general population.
Source
Genetic loci associated with heart rate variability and their effects on cardiac disease risk
Nolte IM,
Munoz ML,
Tragante V,
Amare AT,
Jansen R,
Vaez A,
von der Heyde B,
Avery CL,
Bis JC,
Dierckx B,
van Dongen J,
Gogarten SM
and 153 more — show all
Goyette P,
Hernesniemi J,
Huikari V,
Hwang SJ,
Jaju D,
Kerr KF,
Kluttig A,
Krijthe BP,
Kumar J,
van der Laan SW,
Lyytikäinen LP,
Maihofer AX,
Minassian A,
van der Most PJ,
Müller-Nurasyid M,
Nivard M,
Salvi E,
Stewart JD,
Thayer JF,
Verweij N,
Wong A,
Zabaneh D,
Zafarmand MH,
Abdellaoui A,
Albarwani S,
Albert C,
Alonso A,
Ashar F,
Auvinen J,
Axelsson T,
Baker DG,
de Bakker PIW,
Barcella M,
Bayoumi R,
Bieringa RJ,
Boomsma D,
Boucher G,
Britton AR,
Christophersen I,
Dietrich A,
Ehret GB,
Ellinor PT,
Eskola M,
Felix JF,
Floras JS,
Franco OH,
Friberg P,
Gademan MGJ,
Geyer MA,
Giedraitis V,
Hartman CA,
Hemerich D,
Hofman A,
Hottenga JJ,
Huikuri H,
Hutri-Kähönen N,
Jouven X,
Junttila J,
Juonala M,
Kiviniemi AM,
Kors JA,
Kumari M,
Kuznetsova T,
Kuznetsova T,
Laurie CC,
Lefrandt JD,
Li Y,
Li Y,
Liao D,
Limacher MC,
Lin HJ,
Lindgren CM,
Lubitz SA,
Mahajan A,
McKnight B,
Zu Schwabedissen HM,
Milaneschi Y,
Mononen N,
Morris AP,
Nalls MA,
Navis G,
Neijts M,
Nikus K,
North KE,
O'Connor DT,
Ormel J,
Perz S,
Peters A,
Psaty BM,
Raitakari OT,
Risbrough VB,
Sinner MF,
Siscovick D,
Smit JH,
Smith NL,
Soliman EZ,
Sotoodehnia N,
Staessen JA,
Stein PK,
Stilp AM,
Stolarz-Skrzypek K,
Strauch K,
Sundström J,
Swenne CA,
Syvänen AC,
Tardif JC,
Taylor KD,
Teumer A,
Thornton TA,
Tinker LE,
Uitterlinden AG,
van Setten J,
Voss A,
Waldenberger M,
Wilhelmsen KC,
Willemsen G,
Wong Q,
Zhang ZM,
Zonderman AB,
Cusi D,
Evans MK,
Greiser HK,
van der Harst P,
Hassan M,
Ingelsson E,
Järvelin MR,
Kääb S,
Kähönen M,
Kivimaki M,
Kooperberg C,
Kuh D,
Lehtimäki T,
Lind L,
Nievergelt CM,
O'Donnell CJ,
Oldehinkel AJ,
Penninx B,
Reiner AP,
Riese H,
van Roon AM,
Rioux JD,
Rotter JI,
Sofer T,
Stricker BH,
Tiemeier H,
Vrijkotte TGM,
Asselbergs FW,
Brundel BJJM,
Heckbert SR,
Whitsel EA,
den Hoed M,
Snieder H,
de Geus EJC
Nature communications · 2017 · PMID 28613276 · open access
Questions about rs4899412
What is rs4899412?
rs4899412 is a single position in the genome, in or near the RGS6 gene. Published research associates it with heart rate variability traits (sdnn). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4899412 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4899412 come from?
GWAS Catalog, Nat Commun 2017, PMID:28613276. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants