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Who was studied 77,627 European ancestry cases, 933,894 European ancestry controls.
The effect
Each copy of the T allele carried 1.04 times the odds of Gout (95% confidence interval 1.02-1.05); p = 2 × 10−9.
How common The T allele had a frequency of about 55% in the people studied.
Where it sits Chromosome 18, band 18p11.22 — in an intron of APCDD1.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-11-10.
ClinVar record 1231471NM_153000.5(APCDD1):c.775-102T>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Gout. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Gout. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Gout. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs489837 is a single position in the genome, in or near the APCDD1 gene. Published research associates it with gout. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs489837 linked to?
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs489837 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs489837 come from?
GWAS Catalog, Nature genetics 2024, PMID:39406924. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 1913213Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon3Apple2China (ByteDance, Huawei, Baidu…)0Others13Total19Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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