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Who was studied at least 757,601 European ancestry individuals (MTAG boosted by 455,258 Alzheimer's disease samples).
The effect
Each copy of the G allele shifted the measure 0.0109 higher (95% confidence interval 0.0073-0.0144); p = 2 × 10−9.
Where it sits Chromosome 18, band 18q22.3 — in an intron of TSHZ1.
What each result means
A/ANo copy of the version the research linked to Diastolic blood pressure (MTAG). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Diastolic blood pressure (MTAG). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Diastolic blood pressure (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 39537608 · open access
Questions about rs4891258
What is rs4891258?
rs4891258 is a single position in the genome, in or near the TSHZ1 gene. Published research associates it with diastolic blood pressure (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4891258 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs4891258 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4891258 come from?
GWAS Catalog, Nature communications 2024, PMID:39537608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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