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Who was studied 12,346 East Asian ancestry cases, 225,690 East Asian ancestry controls, 10,976 European ancestry cases, 260,520 European ancestry controls.
The effect
Each copy of the A allele carried 1.26 times the odds of Lung adenocarcinoma (95% confidence interval 1.23-1.3); p = 4 × 10−50.
How common The A allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 15, band 15q25.1 — in the 3′ untranslated region of CHRNA5.
What each result means
A/ATwo copies of the version the research linked to Lung adenocarcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Lung adenocarcinoma. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Lung adenocarcinoma. This is the starting point the study compared everyone against.
Genome medicine · 2026 · PMID 42152146 · open access
Questions about rs4887067
What is rs4887067?
rs4887067 is a single position in the genome, in or near the CHRNA5 gene. Published research associates it with lung adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4887067 linked to?
On MyGeneLog this position is linked to EGFR Mutation-Positive Lung Adenocarcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs4887067 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4887067 come from?
GWAS Catalog, Genome medicine 2026, PMID:42152146. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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