Sensitive

Plasma dihydroorotate levels in chronic kidney disease

SKIC8 · rs4887029

What the study found

Who was studied 4,763 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.169 higher (95% confidence interval 0.13-0.21); p = 9 × 10−17.

How common The T allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 15, band 15q25.1 — in an intron of SKIC8.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Plasma dihydroorotate levels in chronic kidney disease — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Plasma dihydroorotate levels in chronic kidney disease.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Plasma dihydroorotate levels in chronic kidney disease compared to the general population.
Source

Questions about rs4887029

What is rs4887029?

rs4887029 is a single position in the genome, in or near the SKIC8 gene. Published research associates it with plasma dihydroorotate levels in chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4887029 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4887029 come from?

GWAS Catalog, Nature genetics 2023, PMID:37277652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Plasma dihydroorotate levels in chronic kidney disease (rs4887029). MyGeneLog™. https://www.mygenelog.com/variants/rs4887029

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