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Thigh subcutaneous adipose tissue volume

SLC22A3 · rs487060

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10⁻²⁴, with 3 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 37,589 British ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.04 higher (95% confidence interval 0.02-0.06); p = 2 × 10⁻¹¹.

How common The T allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 6, band 6q25.3 — in an intron of SLC22A3.

How common each version is

CT

Korean KRGDB

C 64.8% · T 35.2%

Korean Korea4K

C 64.5% · T 35.5%

Japanese ToMMo

C 71.9% · T 28.1%

World gnomAD

C 54.7% · T 45.3%

World 1000 Genomes

C 60.6% · T 39.4%

World TOPMed

C 55.2% · T 44.8%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Thigh subcutaneous adipose tissue volume. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Thigh subcutaneous adipose tissue volume. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Thigh subcutaneous adipose tissue volume. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

MRI-Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites

Ahmed A, Cule M, Naz A, Thanaj M, Sorokin EP, Odoemelam CS, Whitcher B, Sattar N, Bell JD, Thomas EL, Yaghootkar H

Journal of obesity · 2025 · PMID 40922984 · open access

Questions about rs487060

What is rs487060?

rs487060 is a single position in the genome, in or near the SLC22A3 gene. Published research associates it with thigh subcutaneous adipose tissue volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs487060 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs487060 come from?

GWAS Catalog, Journal of obesity 2025, PMID:40922984. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Thigh subcutaneous adipose tissue volume (rs487060). MyGeneLog™. https://www.mygenelog.com/variants/rs487060

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