Sensitive

Body mass index or osteoarthritis (pleiotropy)

SGO1-AS1 · rs4858223

Where this position leads

What the study found

Who was studied 806,834 European ancestry BMI individuals, 177,517 European ancestry osteoarthritis cases, 649,173 European ancestry controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 3 × 10⁻¹⁵.

Where it sits Chromosome 3, band 3p24.3 — in an intron of SGO1-AS1.

What each result means

C/C No copy of the version the research linked to Body mass index or osteoarthritis (pleiotropy). This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Body mass index or osteoarthritis (pleiotropy). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Body mass index or osteoarthritis (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

A sex- and site-specific relationship between body mass index and osteoarthritis: evidence from observational and genetic analyses

Zhang L, Zhang W, Wu X, Cui H, Yan P, Yang C, Zhao X, Xiao J, Xiao C, Tang M, Wang Y, Chen L

and 10 more — show all

Liu Y, Zou Y, Zhang L, Yang Y, Yao Y, Li J, Liu Z, Yang C, Zhang B, Jiang X

Osteoarthritis and cartilage · 2023 · PMID 36889626

Questions about rs4858223

What is rs4858223?

rs4858223 is a single position in the genome, in or near the SGO1-AS1 gene. Published research associates it with body mass index or osteoarthritis (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4858223 linked to?

On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs4858223 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4858223 come from?

GWAS Catalog, Osteoarthritis and cartilage 2023, PMID:36889626. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Body mass index or osteoarthritis (pleiotropy) (rs4858223). MyGeneLog™. https://www.mygenelog.com/variants/rs4858223

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