Standard

Urate levels

near ARMC10P1 · rs4857338

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 454,183 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0116 lower (95% confidence interval 0.008-0.0152); p = 3 × 10⁻¹⁰.

How common The T allele had a frequency of about 56% in the people studied.

Where it sits Chromosome 3, band 3q11.2 — between genes, 186.2 kb from ARMC10P1.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of Urate levels — no copies of the reported risk allele.

G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Urate levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Urate levels compared to the general population.

Source

Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials

Gill D, Cameron AC, Burgess S, Li X, Doherty DJ, Karhunen V, Abdul-Rahim AH, Taylor-Rowan M, Zuber V, Tsao PS, Klarin D, Evangelou E

and 7 more — show all

Elliott P, Damrauer SM, Quinn TJ, Dehghan A, Theodoratou E, Dawson J, Tzoulaki I

VA Million Veteran Program

Hypertension (Dallas, Tex. : 1979) · 2021 · PMID 33356394 · open access

Questions about rs4857338

What is rs4857338?

rs4857338 is a single position in the genome, in or near the near ARMC10P1 gene. Published research associates it with urate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4857338 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4857338 come from?

GWAS Catalog, Hypertension (Dallas, Tex. : 1979) 2021, PMID:33356394. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Urate levels (rs4857338). MyGeneLog™. https://www.mygenelog.com/variants/rs4857338

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