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Who was studied 1,840 European ancestry cases, 5,163 European ancestry controls and (Liu et al); replicated in 620 European ancestry cases, 2,514 European ancestry controls.
The effect
Each copy of the T allele carried 1.38 times the odds of Primary biliary cholangitis (95% confidence interval 1.28-1.50); p = 2 × 10−16.
How common The T allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 3, band 3q25.33 — in an intron of IL12A-AS1.
What each result means
C/CNo copy of the version the research linked to Primary biliary cholangitis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Primary biliary cholangitis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Primary biliary cholangitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs485499
What is rs485499?
rs485499 is a single position in the genome, in or near the IL12A gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs485499 linked to?
On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs485499?
Subjects that appear in the title or abstract of the same papers as this rsID include liver (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs485499 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs485499 come from?
GWAS Catalog, Nat Genet 2011, PMID:21399635. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
5 5352537222223Reads by AI crawlersClaude5ChatGPT2Google · Gemini5Perplexity3Meta AI7Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others23Total53Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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