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Systemic lupus erythematosus

DGUOK · rs4852324

Where this position leads

Condition: Systemic Lupus Erythematosus

rs4852324 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs4852324 rs4852324 DGUOK

What the study found

Who was studied 1,656 Han Chinese ancestry cases, 3,394 Han Chinese ancestry controls; replicated in 3,256 Han Chinese ancestry cases, 5,667 Han Chinese ancestry controls, 453 Thai ancestry cases, 963 Thai ancestry controls.

The effect Each copy of the T allele carried 1.27 times the odds of Systemic lupus erythematosus (95% confidence interval -); p = 6 × 10−14.

How common The T allele had a frequency of about 76% in the people studied.

Where it sits Chromosome 2, band 2p13.1 — in an intron of DGUOK-AS1.

What each result means

C/C No copy of the version the research linked to Systemic lupus erythematosus. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Systemic lupus erythematosus. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Systemic lupus erythematosus. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians
Yang W, Tang H, Zhang Y, Tang X, Zhang J, Sun L, Yang J, Cui Y, Zhang L, Hirankarn N, Cheng H, Pan HF
and 66 more — show all
Pan HF, Gao J, Lee TL, Sheng Y, Lau CS, Li Y, Chan TM, Yin X, Ying D, Lu Q, Leung AM, Zuo X, Chen X, Tong KL, Zhou F, Diao Q, Tse NK, Xie H, Mok CC, Hao F, Wong SN, Shi B, Lee KW, Hui Y, Ho MH, Liang B, Lee PP, Cui H, Guo Q, Chung BH, Pu X, Liu Q, Zhang X, Zhang C, Chong CY, Fang H, Wong RW, Sun Y, Mok MY, Li XP, Avihingsanon Y, Zhai Z, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Gao F, Shotelersuk V, Kang X, Ying SK, Zhang L, Wong WH, Zhu D, Fung SK, Zeng F, Lai WM, Wong CM, Ng IO, Garcia-Barceló MM, Cherny SS, Shen N, Tam PK, Sham PC, Ye DQ, Yang S, Zhang X, Lau YL
American journal of human genetics · 2013 · PMID 23273568

Questions about rs4852324

What is rs4852324?

rs4852324 is a single position in the genome, in or near the DGUOK gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4852324 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs4852324 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4852324 come from?

GWAS Catalog, Am J Hum Genet 2012, PMID:23273568. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systemic lupus erythematosus (rs4852324). MyGeneLog™. https://www.mygenelog.com/variants/rs4852324

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