Standard
Pulse pressure
near LYPLAL1-AS1 · rs4846567
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,164,961 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.193 mmHg lower (95% confidence interval 0.16-0.23); p = 1 × 10−28.
How common The T allele had a frequency of about 29% in the people studied.
Where it sits Chromosome 1, band 1q41 — between genes, 27.5 kb from LYPLAL1-AS1.
What each result means
G/G
Published research associates this genotype with typical/baseline likelihood of Pulse pressure — no copies of the reported risk allele.
G/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Pulse pressure.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Pulse pressure compared to the general population.
Source
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
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Nature genetics · 2020 · PMID 33230300 · open access
Questions about rs4846567
What is rs4846567?
rs4846567 is a single position in the genome, in or near the near LYPLAL1-AS1 gene. Published research associates it with pulse pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4846567 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4846567 come from?
GWAS Catalog, Nature genetics 2020, PMID:33230300. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Pulse pressure (rs4846567). MyGeneLog™. https://www.mygenelog.com/variants/rs4846567
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