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Who was studied 3,145 European ancestry cases, 3,955 European ancestry controls, 352 African American cases, 1,749 African American controls; replicated in 2,651 cases and their relatives.
The effect
The reported allele is A; the catalogue records no effect size
; p = 8 × 10−9.
How common The A allele had a frequency of about 75% in the people studied.
Where it sits Chromosome 1, band 1q41 — in an intron of TGFB2.
What each result means
A/ATwo copies of the version the research linked to Chronic obstructive pulmonary disease (severe). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Chronic obstructive pulmonary disease (severe). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Chronic obstructive pulmonary disease (severe). This is the starting point the study compared everyone against.
The Lancet. Respiratory medicine · 2014 · PMID 24621683
Questions about rs4846480
What is rs4846480?
rs4846480 is a single position in the genome, in or near the TGFB2 gene. Published research associates it with chronic obstructive pulmonary disease (severe). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4846480 linked to?
On MyGeneLog this position is linked to Chronic Obstructive Pulmonary Disease (COPD). The research behind each link, and its sources, are set out on that condition page.
Does having rs4846480 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4846480 come from?
GWAS Catalog, Lancet Respir Med 2014, PMID:24621683. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 4532136222123Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity3Meta AI6Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others23Total45Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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