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Sum neutrophil eosinophil counts

C1orf132 · rs4844622

Where this position leads

Condition: Blood Cell Counts

rs4844622 Condition: Blood Cell Counts Blood Cell Counts Condition rs4844622 rs4844622 C1orf132

What the study found

Who was studied 170,384 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0243 lower (95% confidence interval 0.016-0.032); p = 7 × 10−9.

How common The T allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 1, band 1q32.2 — in an intron of MIR29B2CHG.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Sum neutrophil eosinophil counts — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Sum neutrophil eosinophil counts.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Sum neutrophil eosinophil counts compared to the general population.
Source
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, Mead D, Bouman H, Riveros-Mckay F, Kostadima MA, Lambourne JJ, Sivapalaratnam S
and 62 more — show all
Downes K, Kundu K, Bomba L, Berentsen K, Bradley JR, Daugherty LC, Delaneau O, Freson K, Garner SF, Grassi L, Guerrero J, Haimel M, Janssen-Megens EM, Kaan A, Kamat M, Kim B, Mandoli A, Marchini J, Martens JHA, Meacham S, Megy K, O'Connell J, Petersen R, Sharifi N, Sheard SM, Staley JR, Tuna S, van der Ent M, Walter K, Wang SY, Wheeler E, Wilder SP, Iotchkova V, Moore C, Sambrook J, Stunnenberg HG, Di Angelantonio E, Kaptoge S, Kuijpers TW, Carrillo-de-Santa-Pau E, Juan D, Rico D, Valencia A, Chen L, Ge B, Vasquez L, Kwan T, Garrido-Martín D, Watt S, Yang Y, Guigo R, Beck S, Paul DS, Pastinen T, Bujold D, Bourque G, Frontini M, Danesh J, Roberts DJ, Ouwehand WH, Butterworth AS, Soranzo N
Cell · 2016 · PMID 27863252 · open access

Questions about rs4844622

What is rs4844622?

rs4844622 is a single position in the genome, in or near the C1orf132 gene. Published research associates it with sum neutrophil eosinophil counts. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4844622 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs4844622 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4844622 come from?

GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Sum neutrophil eosinophil counts (rs4844622). MyGeneLog™. https://www.mygenelog.com/variants/rs4844622

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