Sensitive

Systemic lupus erythematosus

IKBKE · rs4844538

Where this position leads

What the study found

Who was studied 13,377 East Asian ancestry cases, 194,993 East Asian ancestry controls.

The effect Each copy of the A allele carried 1.11 times the odds of Systemic lupus erythematosus (95% confidence interval 1.08-1.14); p = 2 × 10⁻¹⁰.

How common The A allele had a frequency of about 71% in the people studied.

Where it sits Chromosome 1, band 1q32.1 — between genes, 1 kb from IKBKE.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systemic lupus erythematosus compared to the general population.

A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systemic lupus erythematosus.

T/T Published research associates this genotype with typical/baseline likelihood of Systemic lupus erythematosus — no copies of the reported risk allele.

Source

Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus

Yin X, Kim K, Suetsugu H, Bang SY, Wen L, Koido M, Ha E, Liu L, Sakamoto Y, Jo S, Leng RX, Otomo N

and 76 more — show all

Laurynenka V, Kwon YC, Sheng Y, Sugano N, Sugano N, Hwang MY, Li W, Mukai M, Yoon K, Cai M, Ishigaki K, Chung WT, Huang H, Takahashi D, Lee SS, Wang M, Karino K, Shim SC, Zheng X, Miyamura T, Kang YM, Ye D, Nakamura J, Suh CH, Tang Y, Motomura G, Park YB, Ding H, Kuroda T, Choe JY, Li C, Niiro H, Park Y, Shen C, Miyamoto T, Ahn GY, Fei W, Takeuchi T, Shin JM, Li K, Kawaguchi Y, Lee YK, Wang Y, Amano K, Park DJ, Yang W, Tada Y, Yamaji K, Shimizu M, Atsumi T, Suzuki A, Sumida T, Okada Y, Matsuda K, Matsuo K, Kochi Y, Kottyan LC, Weirauch MT, Parameswaran S, Eswar S, Salim H, Chen X, Yamamoto K, Harley JB, Ohmura K, Kim TH, Yang S, Yamamoto T, Kim BJ, Shen N, Ikegawa S, Lee HS, Zhang X, Terao C, Cui Y, Bae SC

Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head

Annals of the rheumatic diseases · 2021 · PMID 33272962 · open access

Questions about rs4844538

What is rs4844538?

rs4844538 is a single position in the genome, in or near the IKBKE gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4844538 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs4844538 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4844538 come from?

GWAS Catalog, Ann Rheum Dis 2020, PMID:33272962. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Systemic lupus erythematosus (rs4844538). MyGeneLog™. https://www.mygenelog.com/variants/rs4844538

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