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Who was studied 349,328 British ancestry individuals; replicated in 144,022 European ancestry,African ancestry,Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.01 higher (95% confidence interval 0.0061-0.0139); p = 6 × 10−11.
Where it sits Chromosome 12, band 12q21.33 — in an intron of POC1B-AS1.
What each result means
A/ATwo copies of the version the research linked to Systolic blood pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Systolic blood pressure. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Systolic blood pressure. This is the starting point the study compared everyone against.
rs4842667 is a single position in the genome, in or near the POC1B-AS1 gene. Published research associates it with systolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4842667 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs4842667 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4842667 come from?
GWAS Catalog, Nature medicine 2024, PMID:38459180. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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