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Who was studied 270,059 British ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0122 higher (95% confidence interval 0.0087-0.0156); p = 5 × 10−12.
Where it sits Chromosome 8, band 8p23.1 — in an intron of MSRA.
What each result means
G/GNo copy of the version the research linked to General factor of neuroticism. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to General factor of neuroticism. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to General factor of neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
Molecular psychiatry · 2020 · PMID 30867560 · open access
Questions about rs4841335
What is rs4841335?
rs4841335 is a single position in the genome, in or near the MSRA gene. Published research associates it with general factor of neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4841335 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs4841335 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4841335 come from?
GWAS Catalog, Molecular psychiatry 2020, PMID:30867560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 413Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others3Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
General factor of neuroticism (rs4841335). MyGeneLog™. https://www.mygenelog.com/variants/rs4841335