0 55Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others5Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 975,353 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0128 higher (95% confidence interval 0.0085-0.0171); p = 1 × 10−8.
How common The A allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 8, band 8p23.1 — between genes, 19.8 kb from XKR6.
What each result means
A/ATwo copies of the version the research linked to General risk tolerance (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to General risk tolerance (MTAG). That is a smaller link than two copies.
T/TNo copy of the version the research linked to General risk tolerance (MTAG). This is the starting point the study compared everyone against.
rs4840523 is a single position in the genome, in or near the XKR6 gene. Published research associates it with general risk tolerance (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4840523 linked to?
On MyGeneLog this position is linked to Adventurousness. The research behind each link, and its sources, are set out on that condition page.
Does having rs4840523 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4840523 come from?
GWAS Catalog, Nature genetics 2019, PMID:30643258. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 55Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others5Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
General risk tolerance (MTAG) (rs4840523). MyGeneLog™. https://www.mygenelog.com/variants/rs4840523