TLR1 · rs4833095
Where this position leads
Condition: Asthma
What the study found
Who was studied 6,685 European ancestry cases, 14,091 European ancestry controls; replicated in 878 European ancestry cases, 2,455 European ancestry controls.
The effect Each copy of the T allele carried 1.20 times the odds of Asthma and hay fever (95% confidence interval 1.14-1.26); p = 5 × 10−12.
How common The T allele had a frequency of about 74% in the people studied.
Where it sits Chromosome 4, band 4p14 — a missense change in TLR1.
What ClinVar records
Classification
Benign; risk factor for Leprosy, susceptibility to, 5, TLR1-related disorder; no assertion criteria provided (0 of 4 stars, 2 submitters), last evaluated 2019-10-18.
ClinVar record 8361 NM_003263.4(TLR1):c.743A>G (p.Asn248Ser)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs4833095 is a single position in the genome, in or near the TLR1 gene. Published research associates it with asthma and hay fever. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include skin, sun and hair (2 papers), allergies (1 papers), liver (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, J Allergy Clin Immunol 2013, PMID:24388013. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Asthma and hay fever (rs4833095). MyGeneLog™. https://www.mygenelog.com/variants/rs4833095