Sensitive

Graves' disease

MAGT1 · rs4826198

Where this position leads

Condition: Graves' Disease

rs4826198 Condition: Graves' Disease Graves' Disease Condition rs4826198 rs4826198 MAGT1

What the study found

Who was studied 1,678 European ancestry cases, 456,942 European ancestry controls, 2,809 East Asian ancestry cases, 172,656 East Asian ancestry controls.

The effect Each copy of the G allele shifted the measure 0.163 higher (95% confidence interval 0.11-0.22); p = 3 × 10−8.

Where it sits Chromosome X, band Xq21.1 — in an intron of MAGT1.

What each result means

A/A No copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs4826198

What is rs4826198?

rs4826198 is a single position in the genome, in or near the MAGT1 gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4826198 linked to?

On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs4826198 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4826198 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Graves' disease (rs4826198). MyGeneLog™. https://www.mygenelog.com/variants/rs4826198

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