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Liver enzyme levels

GGT1 · rs4820599

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 7,751 European ancestry individuals; replicated in 1,005 European ancestry individuals, 3,669 Asian Indian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.01 U/L higher (95% confidence interval 0.005-0.009); p = 4 × 10⁻¹¹.

How common The G allele had a frequency of about 31% in the people studied.

Where it sits Chromosome 22, band 22q11.23 — in an intron of GGT1.

What each result means

A/A No copy of the version the research linked to Liver enzyme levels. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Liver enzyme levels. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Liver enzyme levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes

Yuan X, Waterworth D, Perry JR, Lim N, Song K, Chambers JC, Zhang W, Vollenweider P, Stirnadel H, Johnson T, Bergmann S, Beckmann ND

and 12 more — show all

Li Y, Ferrucci L, Melzer D, Hernandez D, Singleton A, Scott J, Elliott P, Waeber G, Cardon L, Frayling TM, Kooner JS, Mooser V

American journal of human genetics · 2008 · PMID 18940312

What people read about alongside this

Blood sugar and insulin2

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs4820599

What is rs4820599?

rs4820599 is a single position in the genome, in or near the GGT1 gene. Published research associates it with liver enzyme levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs4820599?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs4820599 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4820599 come from?

GWAS Catalog, Am J Hum Genet 2008, PMID:18940312. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Liver enzyme levels (rs4820599). MyGeneLog™. https://www.mygenelog.com/variants/rs4820599

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