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Fibrinogen

PSMG1 · rs4817986

Where this position leads

Condition: Fibrinogen and Blood Clotting

What the study found

Who was studied 91,323 European ancestry individuals; replicated in 8,423 African American individuals, 1,447 Hispanic individuals.

The effect Each copy of the T allele shifted the measure 0.008 lower (95% confidence interval 0.006-0.01); p = 2 × 10⁻¹¹.

How common The T allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 21, band 21q22.2 — between genes, 9.1 kb from LINC02943.

What each result means

G/G No copy of the version the research linked to Fibrinogen. This is the starting point the study compared everyone against.

G/T One copy of the version the research linked to Fibrinogen. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Fibrinogen. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, Rudnicka AR, Trompet S

and 133 more — show all

Mälarstig A, Baumert J, Bis JC, Guo X, Hottenga JJ, Shin SY, Lopez LM, Lahti J, Tanaka T, Yanek LR, Oudot-Mellakh T, Wilson JF, Navarro P, Huffman JE, Zemunik T, Redline S, Mehra R, Pulanic D, Rudan I, Wright AF, Kolcic I, Polasek O, Wild SH, Campbell H, Curb JD, Wallace R, Liu S, Eaton CB, Becker DM, Becker LC, Bandinelli S, Räikkönen K, Widen E, Palotie A, Fornage M, Green D, Gross M, Davies G, Harris SE, Liewald DC, Starr JM, Williams FM, Grant PJ, Spector TD, Strawbridge RJ, Silveira A, Sennblad B, Rivadeneira F, Uitterlinden AG, Franco OH, Hofman A, van Dongen J, Willemsen G, Boomsma DI, Yao J, Swords Jenny N, Haritunians T, McKnight B, Lumley T, Taylor KD, Rotter JI, Psaty BM, Peters A, Gieger C, Illig T, Grotevendt A, Homuth G, Völzke H, Kocher T, Goel A, Franzosi MG, Seedorf U, Clarke R, Steri M, Tarasov KV, Sanna S, Schlessinger D, Stott DJ, Sattar N, Buckley BM, Rumley A, Lowe GD, McArdle WL, Chen MH, Tofler GH, Song J, Boerwinkle E, Folsom AR, Rose LM, Franco-Cereceda A, Teichert M, Ikram MA, Mosley TH, Bevan S, Dichgans M, Rothwell PM, Sudlow CL, Hopewell JC, Chambers JC, Saleheen D, Kooner JS, Danesh J, Nelson CP, Erdmann J, Reilly MP, Kathiresan S, Schunkert H, Morange PE, Ferrucci L, Eriksson JG, Jacobs D, Deary IJ, Soranzo N, Witteman JC, de Geus EJ, Tracy RP, Hayward C, Koenig W, Cucca F, Jukema JW, Eriksson P, Seshadri S, Markus HS, Watkins H, Samani NJ, Wallaschofski H, Smith NL, Tregouet D, Ridker PM, Tang W, Strachan DP, Hamsten A, O'Donnell CJ

VTE Consortium · STROKE Consortium · Wellcome Trust Case Control Consortium 2 (WTCCC2) · C4D Consortium · CARDIoGRAM Consortium

Circulation · 2013 · PMID 23969696

Questions about rs4817986

What is rs4817986?

rs4817986 is a single position in the genome, in or near the PSMG1 gene. Published research associates it with fibrinogen. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4817986 linked to?

On MyGeneLog this position is linked to Fibrinogen and Blood Clotting. The research behind each link, and its sources, are set out on that condition page.

Does having rs4817986 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4817986 come from?

GWAS Catalog, Circulation 2013, PMID:23969696. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Fibrinogen (rs4817986). MyGeneLog™. https://www.mygenelog.com/variants/rs4817986

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