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Lifetime smoking index

SLC24A3 · rs4814873

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁹, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 462,690 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.014 higher (95% confidence interval 0.01-0.018); p = 3 × 10⁻⁹.

How common The C allele had a frequency of about 77% in the people studied.

Where it sits Chromosome 20, band 20p11.23 — in an intron of SLC24A3.

What each result means

C/C Two copies of the version the research linked to Lifetime smoking index. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Lifetime smoking index. That is a smaller link than two copies.

T/T No copy of the version the research linked to Lifetime smoking index. This is the starting point the study compared everyone against.

Source

Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study

Wootton RE, Richmond RC, Stuijfzand BG, Lawn RB, Sallis HM, Taylor GMJ, Hemani G, Jones HJ, Zammit S, Davey Smith G, Munafò MR

Psychological medicine · 2020 · PMID 31689377 · open access

Questions about rs4814873

What is rs4814873?

rs4814873 is a single position in the genome, in or near the SLC24A3 gene. Published research associates it with lifetime smoking index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4814873 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4814873 come from?

GWAS Catalog, Psychological medicine 2020, PMID:31689377. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lifetime smoking index (rs4814873). MyGeneLog™. https://www.mygenelog.com/variants/rs4814873

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