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Asthma

MYT1 · rs4809412

Where this position leads

Condition: Asthma

rs4809412 Condition: Asthma Asthma Condition rs4809412 rs4809412 MYT1

What the study found

Who was studied 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0845 higher (95% confidence interval 0.054-0.115); p = 5 × 10−8.

How common The C allele had a frequency of about 31% in the people studied.

Where it sits Chromosome 20, band 20q13.33 — inside MYT1.

What each result means

A/A No copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Asthma. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs4809412

What is rs4809412?

rs4809412 is a single position in the genome, in or near the MYT1 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4809412 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs4809412 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4809412 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs4809412). MyGeneLog™. https://www.mygenelog.com/variants/rs4809412

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