MYO9B · rs4808569
Where this position leads
Condition: Blood Pressure
Strength of the evidence
Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 295,529 European ancestry individuals, 8,231 Latino individuals, 3,058 African American individuals, 2,029 African British individuals, 7,701 East Asian ancestry individuals, 2,735 South Asian ancestry individuals, 1,979 mixed and unknown ancestry individuals.
The effect Each copy of the C allele shifted the measure 0.162 higher; p = 5 × 10−8.
Where it sits Chromosome 19, band 19p13.11 — in an intron of MYO9B.
rs4808569 is a single position in the genome, in or near the MYO9B gene. Published research associates it with diastolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2017, PMID:27841878. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Diastolic blood pressure (rs4808569). MyGeneLog™. https://www.mygenelog.com/variants/rs4808569