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Who was studied 4,738 European ancestry female cases, 436,834 European ancestry female controls.
The effect
Each copy of the T allele carried 0.78 times the odds of Intrahepatic cholestasis of pregnancy (95% confidence interval 0.74-0.81); p = 1 × 10−30.
How common The T allele had a frequency of about 64% in the people studied.
Where it sits Chromosome 19, band 19q13.12 — between genes, 0.3 kb from SBSN.
What each result means
C/CNo copy of the version the research linked to Intrahepatic cholestasis of pregnancy. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Intrahepatic cholestasis of pregnancy. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Intrahepatic cholestasis of pregnancy. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2026 · PMID 42178310 · open access
Questions about rs4805129
What is rs4805129?
rs4805129 is a single position in the genome, in or near the near SBSN gene. Published research associates it with intrahepatic cholestasis of pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4805129 linked to?
On MyGeneLog this position is linked to Intrahepatic Cholestasis of Pregnancy. The research behind each link, and its sources, are set out on that condition page.
Does having rs4805129 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4805129 come from?
GWAS Catalog, Nature communications 2026, PMID:42178310. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 25482317Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI4Microsoft · Copilot8Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others7Total25Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Intrahepatic cholestasis of pregnancy (rs4805129). MyGeneLog™. https://www.mygenelog.com/variants/rs4805129