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Standard
HDL cholesterol x physical activity interaction (2df test)
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−9.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 7,395 African American inactive individuals, 13,092 African American active individuals, 2,753 Asian ancestry inactive individuals, 3,650 Asian ancestry active individuals, 22,963 European ancestry inactive individuals, 61,939 European ancestry active individuals, 2,829 Hispanic or Latin American inactive individuals, 6,358 Hispanic or Latin American active individuals; replicated in 1,886 African American inactive individuals, 1,892 African American active individuals, 1,217 South African Black ancestry inactive individuals, 389 South African Black ancestry active individuals, 2,494 East Asian ancestry inactive individuals, 1,947 East Asian ancestry active individuals, 724 South Asian ancestry inactive individuals, 1,425 South Asian ancestry active individuals, 41,042 European ancestry inactive individuals, 66,575 European ancestry active individuals, 2,619 Hispanic inactive individuals, 8,802 Hispanic active individuals.
The effect
The reported allele is A; the catalogue records no effect size
; p = 5 × 10−10.
How common The A allele had a frequency of about 38% in the people studied.
Where it sits Chromosome 19, band 19q13.41 — in an intron of FPR3.
How common each version is
AG
KoreanKRGDB
A 44.8% · G 55.2%
KoreanKorea4K
A 43.5% · G 56.5%
KoreanKorea1K
A 44.6% · G 55.4%
Japanese ToMMo
A 42.8% · G 57.2%
World gnomAD
A 35.2% · G 64.8%
World 1000 Genomes
A 37.5% · G 62.5%
World TOPMed
A 34.9% · G 65.1%
By ancestry gnomAD
East Asian
A 46.4% · G 53.6%
European (non-Finnish)
A 40.3% · G 59.7%
African / African American
A 18.7% · G 81.3%
South Asian
A 52.3% · G 47.7%
Admixed American (Latino)
A 43.5% · G 56.5%
Middle Eastern
A 47.6% · G 52.4%
Finnish
A 39.8% · G 60.2%
Ashkenazi Jewish
A 41.8% · G 58.2%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.
What each result means
A/ATwo copies of the version the research linked to HDL cholesterol x physical activity interaction (2df test). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to HDL cholesterol x physical activity interaction (2df test). That is a smaller link than two copies.
G/GNo copy of the version the research linked to HDL cholesterol x physical activity interaction (2df test). This is the starting point the study compared everyone against.
Nature communications · 2019 · PMID 30670697 · open access
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Quoting this page
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