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Who was studied Up to 12,924 European ancestry cases, up to 21,442 European ancestry controls; replicated in Up to 25,683 European ancestry cases, up to 17,015 European ancestry controls.
The effect
Each copy of the G allele carried 1.10 times the odds of Crohn's disease (95% confidence interval 1.06-1.139); p = 2 × 10−10.
How common The G allele had a frequency of about 71% in the people studied.
Where it sits Chromosome 19, band 19q13.32 — between genes, 0.5 kb from PPP5C.
What each result means
G/GTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
rs4802307 is a single position in the genome, in or near the near PPP5C gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4802307 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs4802307 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4802307 come from?
GWAS Catalog, Nature 2012, PMID:23128233. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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